The Drosophila melanogaster Malpighian tubule WWW page

Confocal 3-D reconstructions of tubule-specific enhancer trap lines (Ali Sozen/Douglas Armstrong).
Left: a subset of primary epithelial cells. Right: secondary, or "stellate", cells.

The Drosophila melanogaster Malpighian tubule provides a unique opportunity to perform traditional epithelial physiology, pharmacology and biochemistry on a tissue that is also manipulable with the unique power of Drosophila genetics. Its development is also well understood, meaning that we can obtain a better and more rounded picture of this tissue than almost any other epithelium.

This page is hosted by the Glasgow Group, which concentrates on the molecular physiology of transport and cell signalling processes in tubules.

About the Drosophila tubule

  • An overview (from the Interactive Fly) of genes involved in tubule development

  • NEW! A sensitive map of tubule physiology and pharmacology

  • Epithelial biology

  • Signalling

  • Genomics

    • Drosophila tubule people

    This is a list of principal investigators (or group leaders) believed to focus their research primarily on Drosophila tubules. If you'd like to be included, please email Julian Dow.

      Name

    		 Location email Homepage Publications Research topic
    Julian Dow Glasgow Yes Yes Flybase molecular physiology of transport and cell signalling processes in tubules
    Shireen Davies Glasgow Yes Yes Flybase molecular physiology of transport and cell signalling processes in tubules
    Simon Maddrell Cambridge Yes Yes Flybase transport physiology of tubules
    Mike O'Donnell McMaster Yes Yes Flybase electrophysiology of tubules
    Armin Wessing Giessen Flybase Physiology of (mainly) Drosophila hydei tubules
    Michael Hoch Goettingen Yes Yes Flybase Development of Drosophila tubules
    Jaga Giebultowicz Oregon Yes Flybase Circadian rhythyms in tubules
    Helen Skaer Oxford Yes Flybase Development of Drosophila tubules

    Internet resources

    Tubule-specific

    Drosophila-specific

    Molecular biology

    Julian Dow, 26/3/98